Factors Influencing Goal Attainment in Patients with Post-Stroke Upper Limb Spasticity Following Treatment with Botulinum Toxin A in Real-Life Clinical Practice: Sub-Analyses from the Upper Limb International Spasticity (ULIS)-II Study

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Factors Influencing Goal Attainment in Patients with Post-Stroke Upper Limb Spasticity Following Treatment with Botulinum Toxin A in Real-Life Clinical Practice: Sub-Analyses from the Upper Limb International Spasticity (ULIS)-II Study

In this post-hoc analysis of the ULIS-II study, we investigated factors influencing person-centred goal setting and achievement following botulinum toxin-A (BoNT-A) treatment in 456 adults with post-stroke upper limb spasticity (ULS). Patients with primary goals categorised as passive function had greater motor impairment (p < 0.001), contractures (soft tissue shortening [STS]) (p = 0.006) and ...

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Results from the Upper Limb International Spasticity Study-II (ULIS-II): a large, international, prospective cohort study investigating practice and goal attainment following treatment with botulinum toxin A in real-life clinical management

OBJECTIVE To describe real-life practice and person-centred outcomes in the treatment of poststroke upper limb spasticity with botulinum toxin A (BoNT-A). DESIGN Observational, prospective study. SETTING 84 secondary care centres in 22 countries. PARTICIPANTS 456 adults (≥18 years) with poststroke upper limb spasticity treated with one cycle of BoNT-A. METHODS/OUTCOMES Muscle selection,...

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comparing the efficacy of botulinum toxin with tizanidine in upper limb post stroke spasticity.

background: this study evaluated the efficacy of focal intramuscular injection of botulinum (bont) toxin type a in comparison with oral tizanidine (tzd) in treatment of post-stroke upper limb spasticity. methods: this was a double-blinded randomized clinical trial that recruited 68 patients with post-stroke upper limb spasticity. thirty-four patients received bont (dysport(®)) injections in aff...

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Investigating muscle selection for botulinum toxin-A injections in adults with post-stroke upper limb spasticity.

BACKGROUND Limited empirical information exists regarding botulinum toxin-A injector decision-making practices for adult upper limb post-stroke spasticity. The design of most studies prevents such an assessment, as injection sites and dosage are mandated by researcher protocols. This contrasts to usual injector practices, where individualized decision-making is the standard of care. DESIGN Se...

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Comparing the efficacy of botulinum toxin with tizanidine in upper limb post stroke spasticity

BACKGROUND This study evaluated the efficacy of focal intramuscular injection of botulinum (BoNT) toxin type A in comparison with oral tizanidine (TZD) in treatment of post-stroke upper limb spasticity. METHODS This was a double-blinded randomized clinical trial that recruited 68 patients with post-stroke upper limb spasticity. Thirty-four patients received BoNT (Dysport(®)) injections in aff...

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ژورنال

عنوان ژورنال: Toxins

سال: 2015

ISSN: 2072-6651

DOI: 10.3390/toxins7041192